We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Polyacrylic Acid Functionalized Nanographene as a Nanocarrier for Loading and Controlled Release of Doxorubicin Hydrochloride.
- Authors
Yunping Chen; Yuanyuan Qi; Bin Liu
- Abstract
Graphene nanosheets (GNSs) were synthesized by direct current arc discharge and subsequently functionalized by highly hydrophilic polyacrylic acid (PAA). The loading and release of doxorubicin hydrochloride (DOX) on PAA-functionalized GNSs (PAA-GNSs) were investigated. PAA-GNSs were successfully prepared and verified by atomic force microscope (AFM), Fourier transform infrared (FTIR) and ultraviolet-visible (UV-vis) spectroscopes, and thermo gravimetric analysis (TGA). The PAA-GNSs contained about 10 wt% PAA which significantly improved the solubility of GNSs in aqueous media. The efficient loading of DOX onto the PAA-GNSs is as high as 2.404 ½ 0.167mg/mg at the DOX concentration of 0.36mg/mL. Furthermore, the PPA-GNSs showed strong pH-dependent behavior and efficient slow release ability. Therefore, PAA-GNSs are promising new materials for biological and medical applications.
- Subjects
POLYACRYLIC acid; GRAPHENE; DOXORUBICIN; NANOCARRIERS; THERMOGRAVIMETRY; FOURIER transform infrared spectroscopy; ELECTRIC arc; CONTROLLED release drugs; CHLORIDES
- Publication
Journal of Nanomaterials, 2013, p1
- ISSN
1687-4110
- Publication type
Article
- DOI
10.1155/2013/345738