We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Indicación de biopsia de linfonodo centinela en CDIS de mama. Estudio de factores predictivos de hallazgo de carcinoma invasor posoperatorio.
- Authors
Guesalaga R-T., Paz; Fernández T., Sebastián; Rodríguez G., Javier Ignacio; Camus A., Mauricio; Sánchez G., César; Acevedo C., Francisco; Merino L., Tomás; Abud P., Maritza; Domínguez D., Angélica; Domínguez C., Francisco
- Abstract
Introduction: Ductal carcinoma in situ (DCIS) of the breast is a precursor of invasive carcinoma, accounting for 20-25% of all breast cancer diagnoses. Preoperative percutaneous biopsy does not always identify foci of invasion, as a consequence, the postoperative reports of invasive carcinoma implies another surgery for sentinel lymph node biopsy (SLNB).The objective of this study is to analyze clinical, pathological and radiological factors in patients with a preoperative diagnosis of DCIS that allows to predict the risk of postoperative invasive carcinoma and in whom it would be necessary to perform SLNB to avoid another surgery. Methods: A retrospective study of 304 patients with a preoperative diagnosis of DCIS by percutaneous biopsy was conducted at an institution between 2007-2021. The association between the variables and the diagnosis of invasive carcinoma in the postoperative period was analyzed with logistic regression models using univariate and multivariate analysis. Results: A total of 304 patients with a diagnosis of noninvasive DCIS were identified on percutaneous biopsy and 85 (28%) of them presented invasive carcinoma in the postoperative analysis. In the multivariate analysis, age (OR 1,06; 95% CI 1,01-1,11), lesion size (OR 1,03; 95% CI 1,01-1,05) and negative hormone receptors (OR 5,47; 95% CI 1,61-18,56) were found to be associated with a higher risk of invasion. Conclusion: In patients with DCIS, variables age, size, and hormone receptor status are prognostic factors for invasion in the postoperative biopsy. Therefore, they should be considered for surgical treatment.
- Publication
Revista de Cirugia, 2024, Vol 76, Issue 5, p443
- ISSN
2452-4557
- Publication type
Article
- DOI
10.35687/s2452-454920240052282