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- Title
From Waste to Health: Olive Mill Wastewater for Cardiovascular Disease Prevention.
- Authors
Mattioli, Laura Beatrice; Corazza, Ivan; Budriesi, Roberta; Hrelia, Silvana; Malaguti, Marco; Caliceti, Cristiana; Amoroso, Rosa; Maccallini, Cristina; Crupi, Pasquale; Clodoveo, Maria Lisa; Muraglia, Marilena; Carocci, Alessia; Tardugno, Roberta; Barbarossa, Alexia; Corbo, Filomena
- Abstract
Waste from the agri-food chain represents a valuable reservoir of organic compounds with health-promoting properties. Momast Plus 30 Bio (MP30B) is a derivative obtained from olive-oil wastewater. Its enrichment in hydroxytyrosol (HT) via a patented technique has paved the way for its potential application as a dietary supplement in preventing cardiovascular diseases. MP30B demonstrates no significant alteration in cardiac and vascular parameters in "ex vivo" studies. However, it exhibits a strong ability to remove reactive oxygen species and exerts anti-inflammatory effects, notably reducing the concentration of iNOS and mitigating heart infections in "in vitro" experiments. Furthermore, MP30B slightly decreases the stiffness of the "ex vivo" thoracic aorta, potentially resulting in lowered arterial pressure and enhanced energy transfer to a normal ventricle. Based on these findings, we posit MP30B as a promising extract for cardiovascular disease prevention, and its specific antibacterial properties suggest its utility in preventing cardiac infections.
- Subjects
CARDIOVASCULAR disease prevention; ANTIBIOTICS; ANTI-inflammatory agents; IN vitro studies; HEALTH status indicators; ARTERIAL diseases; RESEARCH funding; OLIVE oil; CARDIOTONIC agents; WASTE products; REACTIVE oxygen species; ARTERIAL pressure; ANTI-infective agents; WATER; ANIMAL experimentation; ENDOTHELIAL cells; ANTIOXIDANTS; HEALTH promotion; DIETARY supplements; NITRIC acid; THORACIC aorta; HEART ventricles
- Publication
Nutrients, 2024, Vol 16, Issue 17, p2986
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16172986