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- Title
OC17.03: Correlation of SNP‐based prenatal cfDNA and clinical findings of a complete mole with a coexisting fetus.
- Authors
Hashimoto, K.; Souter, V.; Dhamankar, R.; Kijacic, D.; Xu, W.; Benn, P.
- Abstract
This article discusses the correlation between SNP-based prenatal cell free DNA (cfDNA) screening and the clinical findings of complete hydatidiform mole with a coexisting fetus (CHMCF). CHMCF is associated with various pregnancy complications, and the study aimed to identify SNP patterns that are compatible with CHMCF. Out of 4,901,007 prenatal cfDNA samples received, 75 had an SNP profile consistent with CHMCF. Most of these cases had prenatal findings compatible with molar change, and a small percentage had fetal abnormalities detected by ultrasound. The article concludes that these rare results should prompt referral for high-risk pregnancy management and further evaluation.
- Subjects
HIGH-risk pregnancy; PREGNANCY complications; CELL-free DNA; PREGNANCY outcomes; MULTIPLE pregnancy; MOLAR pregnancy
- Publication
Ultrasound in Obstetrics & Gynecology, 2024, Vol 64, p44
- ISSN
0960-7692
- Publication type
Article
- DOI
10.1002/uog.27839