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- Title
Vitamin D therapy in chronic kidney disease: a critical appraisal of clinical trial evidence.
- Authors
Yeung, Wing-Chi G; Toussaint, Nigel D; Badve, Sunil V
- Abstract
In people with chronic kidney disease (CKD), the physiology of vitamin D is altered and leads to abnormalities in bone and mineral metabolism which contribute to CKD mineral and bone disorder (CKD-MBD). Observational studies show an association between vitamin D deficiency and increased risk of mortality, cardiovascular disease and fracture in CKD. Although vitamin D therapy is widely prescribed in people with CKD, clinical trials to date have failed to demonstrate a clear benefit of either nutritional vitamin D supplementation or active vitamin D therapy in improving clinical outcomes in CKD. This review provides an updated critical analysis of recent trial evidence on vitamin D therapy in people with CKD.
- Subjects
BONE health; VITAMIN D deficiency; CHRONIC kidney failure; VITAMIN D; RENAL osteodystrophy
- Publication
Clinical Kidney Journal, 2024, Vol 17, Issue 8, p1
- ISSN
2048-8505
- Publication type
Article
- DOI
10.1093/ckj/sfae227