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- Title
Immunity to Sexually Transmitted Bacterial Infections of the Female Genital Tract: Toward Effective Vaccines.
- Authors
Yount, Kacy S.; Darville, Toni
- Abstract
Sexually transmitted infections (STIs) caused by bacterial pathogens Chlamydia trachomatis, Neisseria gonorrhoeae, and Treponema pallidum present significant public health challenges. These infections profoundly impact reproductive health, leading to pelvic inflammatory disease, infertility, and increased susceptibility to other infections. Prevention measures, including antibiotic treatments, are limited by the often-asymptomatic nature of these infections, the need for repetitive and continual screening of sexually active persons, antibiotic resistance for gonorrhea, and shortages of penicillin for syphilis. While vaccines exist for viral STIs like human papillomavirus (HPV) and hepatitis B virus (HBV), there are no vaccines available for bacterial STIs. This review examines the immune responses in the female genital tract to these bacterial pathogens and the implications for developing effective vaccines against bacterial STIs.
- Subjects
SEXUALLY transmitted diseases; GENITALIA infections; NEISSERIA gonorrhoeae; CHLAMYDIA trachomatis; TREPONEMA pallidum
- Publication
Vaccines, 2024, Vol 12, Issue 8, p863
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines12080863