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- Title
vB_CacS-HV1 as a Novel Pahexavirus Bacteriophage with Lytic and Anti-Biofilm Potential against Cutibacterium acnes.
- Authors
Li, Xu; Ding, Wenyan; Li, Zicheng; Yan, Yi; Tong, Yigang; Xu, Jialiang; Li, Mengzhe
- Abstract
Acne vulgaris is a prevalent chronic inflammatory skin disease, most common in adolescence and often persisting into adulthood, leading to severe physical and psychological impacts. The primary etiological factor is Cutibacterium acnes infection. The overuse of antibiotics for acne treatment over recent decades has led to the emergence of antibiotic-resistant Cutibacterium acnes strains. In this study, we isolated and characterized a novel bacteriophage, vB_CacS-HV1, from saliva samples. The average nucleotide identity analysis indicated that vB_CacS-HV1 is a new species within the Pahexavirus genus, enhancing our understanding of this underexplored group. vB_CacS-HV1 demonstrates favorable stability, lacks potentially harmful genetic elements (virulence factors, antibiotic resistance genes, transposons, and integrases), and exhibits potent lytic and anti-biofilm activities against Cutibacterium acnes at low concentrations. These advantages highlight vB_CacS-HV1's potential as a promising antibacterial agent that could possibly be complementary to antibiotics or other treatments for acne therapy.
- Subjects
CUTIBACTERIUM acnes; ANTIBIOTIC overuse; ACNE; ANTIBACTERIAL agents; DRUG resistance in bacteria
- Publication
Microorganisms, 2024, Vol 12, Issue 8, p1566
- ISSN
2076-2607
- Publication type
Article
- DOI
10.3390/microorganisms12081566