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- Title
Is it time to re‐think how we look for teratogenic effects in exposure cohort studies?
- Authors
Friedman, Jan M.
- Abstract
A study published in the journal Paediatric and Perinatal Epidemiology examined the prevalence of major congenital anomalies in children of different ages. The researchers used linked data from Swedish registries and found that the prevalence of major malformations increases from birth to 5 years of age, but the increase is smaller after 1 year of age. Based on these findings, the authors suggest that measuring the frequency of major congenital anomalies diagnosed by 1 year of age is sufficient for most studies looking for associations between maternal drug treatment during pregnancy and infant malformations. The study also highlights the need to update the design of pregnancy pharmacoepidemiological studies to include a wider range of adverse outcomes, such as neurodevelopmental abnormalities, and to analyze patterns of congenital anomalies associated with maternal exposures.
- Subjects
MEDICAL genetics; PREGNANT women; HUMAN abnormalities; DEVELOPMENTAL biology; NOSOLOGY; MATERNAL age; GESTATIONAL diabetes
- Publication
Paediatric & Perinatal Epidemiology, 2024, Vol 38, Issue 6, p532
- ISSN
0269-5022
- Publication type
Article
- DOI
10.1111/ppe.13061