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- Title
IL-15/IL-15Rα Intracellular Trafficking in Human Cells and Protection from Apoptosisa<sup>a</sup>.
- Authors
PERENO, RAFFAELE; GAGGERO, ALESSIA; SCUDELETTI, MARCO; LANZA, LORELLA; MEAZZA, RAFFAELLA; MISHAL, ZOHAR; JASMIN, CLAUDE; INDIVERI, FRANCESCO; FERRINI, SILVANO; AZZARONE, BRUNO
- Abstract
ABSTRACT: IL-15 is an immunostimulatory cytokine sharing with IL-2 the IL-2Rβγ complex. In vivo, IL-15 detection in synovial fluids has been associated with the development of rheumatoid arthritis. A debate exists as to whether IL-15 has the potential to be secreted in meaningful amounts or to act as a pericellular cytokine. Our data show (1) the presence of two IL-15 isoforms displaying signal peptides of different length and the capacity to be secreted restricted to the isoform bearing the longer one; (2) in cells expressing the two isoforms, the existence of different nuclear localization and intracellular trafficking of IL-15 and IL-15Rα and (3) an intercellular microcirculation of IL-15, not detectable with ELISA kits, but displaying a role as an anti-apoptotic factor able to induce the deflection of the TNFR associated factor 2 (TRAF) to IL-15Rα. Our data point to a juxtacrine mechanism of action of IL-15 and suggest a role for IL-15/IL-15Rα in the regulation of apoptosis.
- Publication
Annals of the New York Academy of Sciences, 1999, Vol 876, Issue 1, p236
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.1999.tb07644.x