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- Title
PPARγ Agonist Suppresses TLR4 Expression and TNF-α Production in LPS Stimulated Monocyte Leukemia Cells.
- Authors
Chun-Zhi Wang; Yong Zhang; Xu-Dong Li; Yuan Hu; Zhi-Gang Fang; Dong-Jun Lin; Ruo-Zhi Xiao; Ren-Wei Huang; He-Qing Huang; Pei-Qing Liu; Jia-Jun Liu
- Abstract
It has been well established that inflammation plays a critical role in cancer. Chronic inflammation promotes tumorgenesis and metastasis, which suggests that anti-inflammation drugs could act as a tumor suppressor. It is known that the peroxisome proliferator-activated receptor γ (PPARγ) has been implicated in anti-inflammatory responses; however, the anti-tumor effects of PPARγ have not been intensively investigated. In this study, we examined the effects of PPARγ in cancer. We show that the activation of PPARγ by its agonist rosiglitazone (RGZ) reduces cell proliferation rate in inflammatory and tumor-derived U937 cells. Treatment of RGZ suppresses the expression Toll-like receptor 4 (TLR4) and decreases the production of TNF-α in LPS treated U937 cells. This suggests that NF-κB signaling may be involved in anti-tumor effect of RGZ. Our results demonstrate a role of PPARγ in regulation of NF-κB signaling by modulating TLR4 expression and TNF-α production.
- Subjects
TUMOR necrosis factors; LEUKEMIA; ANTI-inflammatory agents; INFLAMMATION; CYTOKINES
- Publication
Cell Biochemistry & Biophysics, 2011, Vol 60, Issue 3, p167
- ISSN
1085-9195
- Publication type
Article
- DOI
10.1007/s12013-010-9136-6