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- Title
The Multifaceted Roles of USP7: New Therapeutic Opportunities.
- Authors
Nicholson, Benjamin; Suresh Kumar, K. G.
- Abstract
The deubiquitylating enzyme USP7 (HAUSP) sits at a critical node regulating the activities of numerous proteins broadly characterized as tumor suppressors, DNA repair proteins, immune responders, viral proteins, and epigenetic modulators. Aberrant USP7 activity may promote oncogenesis and viral disease making it a compelling target for therapeutic intervention. Disclosed drug discovery programs have identified inhibitors of USP7 such as P005091 with cellular proof of concept and anti-proliferative activity in cancer models. Taken together, USP7 inhibitors hold promise as a new strategy for the treatment of disease.
- Subjects
ENZYMES; PROTEINS; TUMORS; IMMUNITY; CARCINOGENESIS
- Publication
Cell Biochemistry & Biophysics, 2011, Vol 60, Issue 1/2, p61
- ISSN
1085-9195
- Publication type
Article
- DOI
10.1007/s12013-011-9185-5