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- Title
A novel thiamine-derived pigment, pyrizepine, formed by the Maillard reaction.
- Authors
Igoshi, Asuka; Noda, Kyoko; Murata, Masatsune
- Abstract
To find a Maillard pigment derived from thiamine, a solution containing glucose and thiamine was heated and analyzed with high-performance liquid chromatography equipped with diode-array detection. As a result, a unique peak showing an absorption maximum at 380 nm was detected. This peak was then isolated from a reaction solution containing glucose, lysine and thiamine, and was identified as 1-(2-methyl-6,9-dihydro-5H-pyrimido[4,5-e][1,4]diazepin-7-yl)ethan-1-one using instrumental analyses. This compound, named pyrizepine, was a novel yellow pigment having a fused ring consisting of pyrimidine and diazepine. Pyrizepine was a major low-molecular-weight pigment in the reaction solution. The structure suggests that pyrizepine is formed by condensation reaction between a degradation product of thiamine and a tetrosone derivative formed from glucose by the Maillard reaction.
- Subjects
MAILLARD reaction; VITAMIN B1
- Publication
Bioscience, Biotechnology & Biochemistry, 2018, Vol 82, Issue 8, p1425
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2018.1466687