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- Title
Bisphenol A exerts estrogenic effects by modulating CDK1/2 and p38 MAP kinase activity.
- Authors
Hee-Seok Lee; Eun-Jung Park; Jae-Ho Oh; Guiim Moon; Myung-Sil Hwang; Sang-Yub Kim; Min-Ki Shin; Young-Ho Koh; Jin-Hyang Suh; Hui-Seung Kang; Ju-Hong Jeon; Gyu-Seek Rhee; Jin-Hwan Hong
- Abstract
The article discusses a study that demonstrated how bisphenol A (BPA) exerts estrogenic effects through the modulation of CDK1/2 and p38 mitogen-activated protein (MAP) kinase activity. The researchers used a fluorescence polarization competitive binding assay to show that BPA binds estrogen receptor (ER)-alpha and ER-beta. The results indicate that BPA mimics ER-dependent estrogenic activity by targeting the proteins regulating the cell cycle and p38 MAPK.
- Subjects
PHYSIOLOGICAL effects of chemicals; BISPHENOL A; PHYSIOLOGICAL effects of estrogen; MITOGEN-activated protein kinase regulation; ESTROGEN receptors; CELL cycle regulation
- Publication
Bioscience, Biotechnology & Biochemistry, 2014, Vol 78, Issue 8, p1371
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2014.921557