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- Title
Pd‐Catalyzed Selective Bifunctionalization of 3‐Iodo‐o‐Carborane by Pd Migration.
- Authors
Ge, Yixiu; Zhang, Jie; Qiu, Zaozao; Xie, Zuowei
- Abstract
A palladium‐catalyzed highly selective 3,4‐bifunctionalization of 3‐I‐o‐carborane has been developed, leading to the preparation of 3‐alkenyl‐4‐R‐o‐carboranes (R=alkyl, alkynyl, aryl, allyl, CN, and amido) in high to excellent yields. This protocol combines the sequential activation of cage B(3)−I and B(4)−H bonds by Pd migration from exo‐alkenyl sp2 C to cage B(4), which is driven by thermodynamic force. This represents a brand‐new strategy for selective bifunctionalization of carboranes with two different substituents.
- Subjects
PALLADIUM
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 12, p4881
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201914500