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- Title
Asymmetric Alkenylation of Enones and Imines Enabled by A Highly Efficient Aryl to Vinyl 1,4‐Rhodium Migration.
- Authors
Zhang, Shu‐Sheng; Hu, Tian‐Jiao; Li, Meng‐Yao; Song, Yi‐Kang; Yang, Xiao‐Di; Feng, Chen‐Guo; Lin, Guo‐Qiang
- Abstract
The asymmetric rhodium‐catalyzed alkenylation of enones and imines with arylboronic acids has been developed. A highly controllable aryl to vinyl 1,4‐rhodium migration is the key step. Stereodefined vinyl moieties were installed in excellent enantioselectivies for most examined examples. DFT calculations reveal that the driving force of this rhodium migration is a kinetically favored process.
- Subjects
ALKENYLATION; CARBONYL compounds; IMINES; RHODIUM; BORONIC acids
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 11, p3425
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201813585