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- Title
Chemical Design of Non‐Ionic Polymer Brushes as Biointerfaces: Poly(2‐oxazine)s Outperform Both Poly(2‐oxazoline)s and PEG.
- Authors
Morgese, Giulia; Verbraeken, Bart; Ramakrishna, Shivaprakash N.; Gombert, Yvonne; Cavalli, Emma; Rosenboom, Jan‐Georg; Zenobi‐Wong, Marcy; Spencer, Nicholas D.; Hoogenboom, Richard; Benetti, Edmondo M.
- Abstract
Abstract: The era of poly(ethylene glycol) (PEG) brushes as a universal panacea for preventing non‐specific protein adsorption and providing lubrication to surfaces is coming to an end. In the functionalization of medical devices and implants, in addition to preventing non‐specific protein adsorption and cell adhesion, polymer‐brush formulations are often required to generate highly lubricious films. Poly(2‐alkyl‐2‐oxazoline) (PAOXA) brushes meet these requirements, and depending on their side‐group composition, they can form films that match, and in some cases surpass, the bioinert and lubricious properties of PEG analogues. Poly(2‐methyl‐2‐oxazine) (PMOZI) provides an additional enhancement of brush hydration and main‐chain flexibility, leading to complete bioinertness and a further reduction in friction. These data redefine the combination of structural parameters necessary to design polymer‐brush‐based biointerfaces, identifying a novel, superior polymer formulation.
- Subjects
POLYETHYLENE glycol; PROTEINS; MEDICAL equipment; POLYMERS; OXAZOLINE
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 36, p11841
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201805620