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- Title
Simultaneous Fenton‐like Ion Delivery and Glutathione Depletion by MnO<sub>2</sub>‐Based Nanoagent to Enhance Chemodynamic Therapy.
- Authors
Lin, Li‐sen; Song, Jibin; Song, Liang; Ke, Kaimei; Liu, Yijing; Zhou, Zijian; Shen, Zheyu; Li, Juan; Yang, Zhen; Tang, Wei; Niu, Gang; Yang, Huang‐hao; Chen, Xiaoyuan
- Abstract
Abstract: Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells by converting endogenous H2O2 into the highly toxic hydroxyl radical (.OH). There is a paucity of Fenton‐like metal‐based CDT agents. Intracellular glutathione (GSH) with .OH scavenging ability greatly reduces CDT efficacy. A self‐reinforcing CDT nanoagent based on MnO2 is reported that has both Fenton‐like Mn2+ delivery and GSH depletion properties. In the presence of HCO3−, which is abundant in the physiological medium, Mn2+ exerts Fenton‐like activity to generate .OH from H2O2. Upon uptake of MnO2‐coated mesoporous silica nanoparticles (MS@MnO2 NPs) by cancer cells, the MnO2 shell undergoes a redox reaction with GSH to form glutathione disulfide and Mn2+, resulting in GSH depletion‐enhanced CDT. This, together with the GSH‐activated MRI contrast effect and dissociation of MnO2, allows MS@MnO2 NPs to achieve MRI‐monitored chemo–chemodynamic combination therapy.
- Subjects
GLUTATHIONE; OXIDATION-reduction reaction; MAGNESIUM oxide; SILICA nanoparticles; POTASSIUM permanganate
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 18, p4996
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201712027