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- Title
On the Role of Chirality in Guiding the Self-Assembly of Peptides.
- Authors
Basak, Shibaji; Singh, Ishwar; Ferranco, Annaleizle; Syed, Jebreil; Kraatz, Heinz ‐ Bernhard
- Abstract
Homochirality in peptides is crucial in sustaining 'like-like' intermolecular interactions that allow the formation of assemblies and aggregates and is ultimately responsible for the resulting material properties. With the help of a series of stereoisomers of the tripeptide F-F-L, we demonstrate the critical role that peptide stereochemistry plays in the self-assembly of peptides, guided by molecular recognition, and for self-sorting. Homochiral self-assemblies are thermally and mechanically more robust compared to heterochiral self-assemblies. Morphological studies of the multicomponent peptide systems showed that aggregates formed from homochiral peptides possessed a uniform nano-fibrous structure, whereas heterochiral systems resulted in self-sorted systems with a heterogeneous morphology. In essence, homochiral peptides form the stronger aggregates, which may be one of reasons why homochirality is preferred in living systems.
- Subjects
CHIRALITY; PEPTIDES; MOLECULAR self-assembly; INTERMOLECULAR interactions; MOLECULAR recognition; CLUSTERING of particles; STEREOCHEMISTRY
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 43, p13473
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201706162