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- Title
A Catalyst-Controlled Aerobic Coupling of ortho-Quinones and Phenols Applied to the Synthesis of Aryl Ethers.
- Authors
Huang, Zheng; Lumb, Jean ‐ Philip
- Abstract
ortho-Quinones are underutilized six-carbon-atom building blocks. We herein describe an approach for controlling their reactivity with copper that gives rise to a catalytic aerobic cross-coupling with phenols. The resulting aryl ethers are generated in high yield across a broad substrate scope under mild conditions. This method represents a unique example where the covalent modification of an ortho-quinone is catalyzed by a transition metal, creating new opportunities for their utilization in synthesis.
- Subjects
QUINONE synthesis; ETHERS; DIARYL compounds; COPPER catalysts; PHENOLS; TRANSITION metal catalysts
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 38, p11715
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201606359