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- Title
Subjective hypnotic efficacy of trazodone and zolpidem in DSMIII–R primary insomnia.
- Authors
Walsh, James K.; Erman, Milton; Erwin, C. W.; Jamieson, Andrew; Mahowald, Mark; Regestein, Quentin; Scharf, Martin; Tigel, P.; Vogel, Gerald; Ware, J. Catesby
- Abstract
Trazodone is an antidepressant which is used at low doses as a hypnotic. The hypnotic efficacy of trazodone in non-depressed insomniacs is unknown, especially in comparison to hypnotic medications such as zolpidem. Following a placebo screening week, DSM-IIIR defined primary insomniacs were randomized into a parallel-group, double-blind, 14-day comparison of trazodone 50 mg, zolpidem 10 mg and placebo. Patients completed daily morning questionnaires and weekly office visits. Self-reported sleep latencies were compared by the Cox proportional hazards regression technique; self-reported sleep duration by ANOVA. During treatment Week 1, both drugs produced significantly shorter self-reported sleep latencies and longer self-reported sleep durations than placebo. Self-reported sleep latency was significantly shorter with zolpidem than with trazodone. During Week 2, only the zolpidem group maintained a significantly shorter sleep latency than the placebo group, and self-reported sleep duration did not vary significantly among groups. The incidence of adverse events was low in all groups. Both trazodone and zolpidem improved self-reported sleep latency and duration of non-depressed, primary insomniacs; zolpidem was somewhat more efficacious at the doses studied. © 1998 John Wiley & Sons, Ltd.
- Subjects
SIDE effects of psychiatric drugs; HYPNOTICS; ZOLPIDEM; INSOMNIA; SLEEP disorders
- Publication
Human Psychopharmacology: Clinical & Experimental, 1998, Vol 13, Issue 3, p191
- ISSN
0885-6222
- Publication type
Article
- DOI
10.1002/(SICI)1099-1077(199804)13:3<191::AID-HUP972>3.0.CO;2-X