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- Title
The BAR Score Predicts and Stratifies Outcomes Following Liver Retransplantation: Insights From a Retrospective Cohort Study.
- Authors
Krendl, Felix J.; Fodor, Margot; Buch, Madita L.; Singh, Jessica; Esser, Hannah; Cardini, Benno; Resch, Thomas; Maglione, Manuel; Margreiter, Christian; Schlosser, Lisa; Hell, Tobias; Schaefer, Benedikt; Zoller, Heinz; Schneeberger, Stefan; Oberhuber, Rupert
- Abstract
Liver retransplantation (reLT) yields poorer outcomes than primary liver transplantation, necessitating careful patient selection to avoid futile reLT. We conducted a retrospective analysis to assess reLT outcomes and identify associated risk factors. All adult patients who underwent a first reLT at the Medical University of Innsbruck from 2000 to 2021 (N = 111) were included. Graft- and patient survivalwere assessed via Kaplan-Meier plots and log-rank tests. Uni- and multivariate analyses were performed to identify independent predictors of graft loss. Five-year graft- and patient survival rates were 64.9% and 67.6%, respectively. The balance of risk (BAR) score was found to correlate with and be predictive of graft loss and patient death. The BAR score also predicted sepsis (AUC 0.676) and major complications (AUC 0.720). Multivariate Cox regression analysis identified sepsis [HR 5.179 (95% CI 2.575-10.417), p < 0.001] as the most significant independent risk factor for graft loss. At a cutoff of 18 points, the 5 year graft survival rate fell below 50%. The BAR score, a simple and easy to use score available at the time of organ acceptance, predicts and stratifies clinically relevant outcomes following reLT and may aid in clinical decision-making.
- Subjects
COHORT analysis; REGRESSION analysis; OVERALL survival; MULTIVARIATE analysis; LOG-rank test
- Publication
Transplant International, 2024, Vol 37, p1
- ISSN
0934-0874
- Publication type
Article
- DOI
10.3389/ti.2024.12104