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- Title
Mutagenicity of diagnostic and therapeutical doses of radiopharmaceutical iodine-131 in Wistar rats.
- Authors
Düsman, Elisângela; Berti, Alessandra; Mariucci, Rosinete; Lopes, Nilson; Vicentini, Veronica
- Abstract
Iodine-131 (I) is a radioisotope used for the diagnosis and treatment of thyroidal disorders such as hyperthyroidism and cancer. During its decay, I emits beta particles and gamma rays; its physical half-life is 8 days, and it is accumulated preferentially in the thyroid tissue. This study aimed to evaluate the cytotoxicity and mutagenicity of diagnostic and therapeutic doses of I using bone marrow cells of rats treated in vivo in a test system with a single dose by gavage. Concentrations of 5, 25, 50 and 250 μCi in 1 ml of water were used, and after 24 h, the animals were killed. Also, a concentration of 25 μCi/ml of water was used, and the animals were killed after 5 days. The results showed that no concentration of I was cytotoxic and that all concentrations were mutagenic. As a result, there was no statistically significant difference detected by the χ test in the induction of chromosomal aberrations between the different doses. Thus, the present study demonstrated a significant increase in chromosomal aberration in bone marrow cells exposed to I regardless of the dose or the treatment time.
- Subjects
HYPERTHYROIDISM treatment; IODINE isotope decay; BETA rays; PHYSIOLOGICAL effects of gamma rays; MUTAGENICITY testing; LABORATORY rats
- Publication
Radiation & Environmental Biophysics, 2011, Vol 50, Issue 4, p579
- ISSN
0301-634X
- Publication type
Article
- DOI
10.1007/s00411-011-0380-y