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- Title
Creation of an animal model for long gap pure esophageal atresia.
- Authors
Glenn, Ian; Bruns, Nicholas; Gabarain, Gabriel; Craner, Domenic; Schomisch, Steve; Ponsky, Todd; Glenn, Ian C; Bruns, Nicholas E; Craner, Domenic R; Schomisch, Steve J; Ponsky, Todd A
- Abstract
<bold>Introduction: </bold>Long gap pure esophageal atresia (LGPEA) is a congenital disorder in which the esophagus is in discontinuity, and the proximal and distal ends cannot be anastomosed in a primary fashion. No animal model for pure esophageal atresia exists. Here we describe a survival animal model for LGPEA, which will ultimately serve to test novel devices and techniques to restore continuity.<bold>Methods: </bold>A non-survival study was first conducted in six rabbits to refine a protocol for the survival model. An open gastrostomy tube was placed, followed by a partial esophagectomy. Next, a survival study was performed with seven rabbits in which the same procedures were performed. Finally, the procedure was optimized in domestic swine.<bold>Results: </bold>Despite developing the techniques and gaining valuable information in the non-survival study, none of the rabbits in the survival portion of the study lived beyond post-operative day four. Due to this complication with the rabbit, the LGPEA model was attempted in a porcine model. The pig survived to post-operative day ten, and was healthy enough to be used for further study.<bold>Conclusion: </bold>A porcine model of long gap pure esophageal atresia was developed which is effective and feasible to be used for testing new methods of treatment of LGPEA.
- Subjects
ESOPHAGEAL atresia; CONGENITAL disorders; GASTROSTOMY; ESOPHAGECTOMY; ANIMAL models in research; THERAPEUTICS; ESOPHAGEAL surgery; ANIMALS; BIOLOGICAL models; RABBITS; SWINE
- Publication
Pediatric Surgery International, 2017, Vol 33, Issue 2, p197
- ISSN
0179-0358
- Publication type
journal article
- DOI
10.1007/s00383-016-4014-y