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- Title
A case of relapsing spinal atypical teratoid/rhabdoid tumor (AT/RT) responding to vinorelbine, cyclophosphamide, and celecoxib.
- Authors
Gotti, Giacomo; Biassoni, Veronica; Schiavello, Elisabetta; Spreafico, Filippo; Antonelli, Manila; Calareso, Giuseppina; Pecori, Emilia; Gandola, Lorenza; Massimino, Maura
- Abstract
Introduction:: Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is a highly aggressive neoplasm which prevalently affects children and is characterized by a severe prognosis. Case presentation:: The authors describe an extremely rare case of a primary spinal AT/RT that occurred in a young girl. The patient underwent a wide surgical resection of a lumbar mass, followed by aggressive chemotherapy, myeloablative treatment, and local radiotherapy. After 7 months from the end of the treatment, the patient experienced local recurrence and was treated with surgery and second-line chemotherapy with antiangiogenic purposes, consisting of oral vinorelbine, cyclophosphamide, and celecoxib. Treatment was well tolerated, and patient was still alive 36 months after diagnosis. Conclusion:: The peculiarity of this case report is the clinical-radiological response to a metronomic therapy in a case of early-relapsing spinal AT/RT despite previous maximal surgery, chemotherapy, and radiotherapy.
- Subjects
VINORELBINE; CYCLOPHOSPHAMIDE; CELECOXIB; ANTIARTHRITIC agents; TUMOR treatment
- Publication
Child's Nervous System, 2015, Vol 31, Issue 9, p1621
- ISSN
0256-7040
- Publication type
Article
- DOI
10.1007/s00381-015-2755-x