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- Title
Index of glucose effectiveness derived from oral glucose tolerance test.
- Authors
Nagasaka, Shoichiro; Kusaka, Ikuyo; Yamashita, Koh; Funase, Yoshiko; Yamauchi, Keishi; Katakura, Masafumi; Ishibashi, Shun; Aizawa, Toru
- Abstract
Aim of this study was to formulate an index for glucose effectiveness (Sg), SgIo, based on 3-point (0, 30 and 120 min) 75 g oral glucose tolerance test (OGTT). The equation for SgI was developed in the Chikuma cohort ( n = 502). Firstly, post-loading plasma glucose without insulin action and Sg (PPG-without insulin and Sg) was calculated as follows: fasting plasma glucose (mg/dl) + [0.75 × 75,000]/[0.19 × BW(kg) × 10]. Secondly, 'PPG-without insulin/with Sg' was obtained from inverse correlation between logDI and 2-h post-glucose plasma glucose at OGTT (2hPG) in each glucose tolerance category: DI denotes oral disposition index, a product of the Matsuda Index and δIRI/δPG. Thirdly, expected 2hPG (2hPG) of a given subject was obtained from the regression, and the ratio of 2hPG to 2hPG (2hPG/2hPG) was determined as an adjustment factor. Lastly, SgI ([mg/dl]/min) was calculated as $$ \frac{{[{\text{PPG}} \hbox{-} {\text{without}}\;{\text{insulin}}\;{\text{and}}\;{\text{Sg}}] - [{\text{PPG}} \hbox{-} {\text{without}}\;{\text{insulin}}/{\text{with}}\;{\text{Sg}}] \times [(2{\text{hPG}})/(2{\text{hPG}}_{\text{E}})]}}{120} $$. SgI was validated against Sg obtained by frequently sampled intravenous glucose tolerance test in the Jichi cohort ( n = 205). Also, the accuracy of prediction of Sg by SgIo was tested by the Bland-Altman plot. SgI was 3.61 ± 0.73, 3.17 ± 0.74 and 2.15 ± 0.60 in subjects with normal glucose tolerance (NGT), non-diabetic hyperglycemia and diabetes, respectively, in the Chikuma cohort. In the Jichi cohort, SgI was significantly correlated with Sg in the entire group ( r = 0.322, P < 0.001) and in subjects with NGT ( r = 0.286, P < 0.001), and SgIo accurately predicted Sg. In conclusion, SgI could be a simple, quantitative index for Sg.
- Subjects
BLOOD sugar; GLUCOSE tolerance tests; BODY mass index; HYPERGLYCEMIA; TYPE 2 diabetes
- Publication
Acta Diabetologica, 2012, Vol 49, p195
- ISSN
0940-5429
- Publication type
Article
- DOI
10.1007/s00592-012-0417-y