We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Autophagy in infection, inflammation and immunity.
- Authors
Deretic, Vojo; Saitoh, Tatsuya; Akira, Shizuo
- Abstract
Autophagy is a fundamental eukaryotic pathway that has multiple effects on immunity. Autophagy is induced by pattern recognition receptors and, through autophagic adaptors, it provides a mechanism for the elimination of intracellular microorganisms. Autophagy controls inflammation through regulatory interactions with innate immune signalling pathways, by removing endogenous inflammasome agonists and through effects on the secretion of immune mediators. Moreover, autophagy contributes to antigen presentation and to T cell homeostasis, and it affects T cell repertoires and polarization. Thus, as we discuss in this Review, autophagy has multitiered immunological functions that influence infection, inflammation and immunity.
- Subjects
AUTOPHAGY; INFECTION; INFLAMMATION; IMMUNITY; BIOLOGICAL transport; LYMPHOCYTES
- Publication
Nature Reviews Immunology, 2013, Vol 13, Issue 10, p722
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri3532