We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Relación entre gammaglutamil-transferasa y rigidez arterial en pacientes con infección por VIH.
- Authors
Martínez-Ayala, P.; Alanis-Sánchez, G. A.; González-Hernández, L. A.; Andrade-Villanueva, J. F.; Ramos-Becerra, C.; Ibarra-Jiménez, R. L.; Félix-Castro, M. A.; Soria-Rodríguez, R.; Ponce Orozco, O.; Cardona-Müller, D.; Cardona-Muñoz, E. G.; Loza-Salazar, A. D.; González-Peñ, D. F.; Serrano-Suárez, N.
- Abstract
Intorduction. With modern antiretroviral therapy, early diagnosis and treatment, life expectancy of human immunodeficiency virus (HIV)-infected subjects is similar to that of the general population. As a result, cardiovascular disease (CVD) in HIV, besides having a higher incidence, is also the most common cause of death among subjects receiving antiretroviral therapy. However, it is not clear to which degree the associated inflammatory state and the adverse effects of antiretroviral therapy contribute to this higher risk of CDV. For this reason, identification of subclinical changes in the CV system, such as arterial stiffness, is important for a correct cardiovascular risk evaluation in newly diagnosed HIV individuals. Carotid-femoral pulse wave velocity (cfPWV) is an independent biomarker of CVD and is considered the gold standard to assess arterial stiffness. For this reason, the aim of the present study was to evaluate the association of traditional cardiovascular risk factors, immunological state, viral load, hepatic and renal function with cfPWV in HIV individuals without treatment (naïve). Material and Methods. We conducted a cross-sectional study in HIV naïve patients. We measured cfPWV by aplanation tonometry as marker of arterial stiffness. Likewise, we assessed the associations between viral load (number of viral copies), immunological state (T CD4 and CD8 lymphocytes), serum lipids (total cholesterol, triglycerides, and low and high density lipoproteins), C-reactive protein (PCR), and kidney (serum creatinine and creatinine clearance) and liver function (albumin, gamma-glutamyltransferase, aspartate aminotransferase and alanine transaminase). Results. Fifty-one individuals (90.2% males) were included in the study. Mean age was 33±10 years old with a smoking prevalence of 70.5%. Additionally, individuals had a prevalence of high density lipoprotein below 40 mg/dl of 79.5%. We found a positive association between gamma-glutamyl transferase and cfPWV (rho=0.399, p<0.01). However, we did not observe any associations between the rest of the parameters of kidney function, serum lipids, immunological state, viral load or PCR with arterial stiffness. Discussion. Individuals HIV treatment naïve exhibited an association between arterial stiffness and GGT, a contributor of oxidative stress. The traditional risk factors, together with parameters of viral load, immunological state, smoking habits, liver and renal function were not associated with arterial stiffness.
- Publication
Revista Médica MD, 2018, Vol 9, Issue 4, p299
- ISSN
2007-8188
- Publication type
Article