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- Title
Production of YP170 Vitellogenins Promotes Intestinal Senescence in Caenorhabditis elegans.
- Authors
Sornda, Thanet; Ezcurra, Marina; Kern, Carina; Galimov, Evgeniy R; Au, Catherine; de la Guardia, Yila; Gems, David
- Abstract
During aging, etiologies of senescence cause multiple pathologies, leading to morbidity and death. To understand aging requires identification of these etiologies. For example, Caenorhabditis elegans hermaphrodites consume their own intestinal biomass to support yolk production, which in later life drives intestinal atrophy and ectopic yolk deposition. Yolk proteins (YPs; vitellogenins) exist as three abundant species: YP170, derived from vit-1-vit-5; and YP115 and YP88, derived from vit-6. Here, we show that inhibiting YP170 synthesis leads to a reciprocal increase in YP115/YP88 levels and vice versa, an effect involving posttranscriptional mechanisms. Inhibiting YP170 production alone, despite increasing YP115/YP88 synthesis, reduces intestinal atrophy as much as inhibition of all YP synthesis, which increases life span. By contrast, inhibiting YP115/YP88 production alone accelerates intestinal atrophy and reduces life span, an effect that is dependent on increased YP170 production. Thus, despite copious abundance of both YP170 and YP115/YP88, only YP170 production is coupled to intestinal atrophy and shortened life span. In addition, increasing levels of YP115/YP88 but not of YP170 increases resistance to oxidative stress; thus, longevity resulting from reduced vitellogenin synthesis is not attributable to oxidative stress resistance.
- Subjects
CAENORHABDITIS elegans; VITELLOGENINS; OLD age; AGING; LIFE spans; PROTEIN metabolism; NEMATODE physiology; ANIMAL experimentation; COMPARATIVE studies; INTERSEXUALITY; INTESTINAL mucosa; LONGEVITY; RESEARCH methodology; MEDICAL cooperation; RESEARCH; OXIDATIVE stress; EVALUATION research; ATROPHY
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2019, Vol 74, Issue 8, p1180
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glz067