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- Title
不同训练方法对大鼠骨折后脊髓功能恢复的影响.
- Authors
卫永鲲; 马慧玲; 欧阳振; 杨立峰; 雷 涛
- Abstract
Objective:To analyze the Effects of different training methods on the recovery of spinal cord function after fracture in rats. Methods: Forty SD rats were randomly selected to establish the model of fracture combined with spinal cord injury, and another 10 rats were selected as the normal group. SD rats were randomly divided into model group, weight-loss training group, swimming training group and rotating cage training group. The motor function of rats was evaluated before and after injury. The motor evoked potential (MEP), brain-derived nerve growth factor (BDNF), neuron specific enolase (NSE) and cleaved caspase-3 expression in spinal cord tissue, cross-sectional area and diameter of muscle fibers were measured 35 days after operation. Results: After the injury, the motor function scores of the rats in the operation group decreased. After training in different ways, the score of motor function of rats increased, and the difference was statistically significant (P<0.05). On the 35th day after operation, compared with the model group, the latency of motor evoked potential in the training group was shortened, the amplitude, the expression of BDNF and NSE, the cross-sectional area and diameter of muscle fiber were increased, and the expression of cleaved caspase-3 was decreased, and the difference between the 14 d and 35 d was statistically significant (P<0.05). Among them, the test results of each index of the weight-loss plate training group are the best. Coclusions:Three training methods can promote the recovery of spinal cord function after fracture in rats, among which the recovery effect of weight-loss plate training group > swimming training group > rotating cage training group.
- Subjects
NERVE growth factor; SWIMMING training; EVOKED potentials (Electrophysiology); SPINAL cord injuries; SPINAL cord; BODY-weight-supported treadmill training
- Publication
Progress in Modern Biomedicine, 2020, Vol 20, Issue 19, p3621
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2020.19.004