We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
瓣膜手术同期射频消融改良迷宫术治疗心脏瓣膜病并发房颤患者的疗效 及对血清细胞因子的影响.
- Authors
苏哲; 郑霄; 吕向妮; 张海燕; 张平
- Abstract
Objective: To analyze the efficacy of radiofrequency ablation combined with modified maze in the treatment of patients with atrial fibrillation caused by valvular disease and its effect on the serum cytokines. Methods: 80 patients with valvular heart disease complicated with atrial fibrillation were divided into control group and observation group according to simple random method, 40 cases in each group, the control group was treated with cardiac valve replacement, while the observation group was treated with valve surgery concomitant radiofrequency ablation modified maze. The sinus rhythm reversion, operation conditions, changes of cardiac function, levels of metalloproteinase-1(TIMP-1), matrix metalloproteinase-1(MMP-1) and matrix metalloproteinase-9(MMP-9) before and after operation, and occurrence of postoperative complications were compared between the two groups. Results: The sinus rhythm conversion rates of observation group on the day after operation, at 1, 3, 6 month after operation were significant higher than those of the control group(P<0.05). The extracorporeal circulation time, aortic occlusion time and postoperative 24 h drainage volume were significantly higher than those in the control group(P<0.05). there was no significant difference between the two groups in the ventilator usage time and intensive care unit time(P>0.05). At six months after operation, the left ventricular end diastolic diameter, left ventricular end systolic diameter, serum levels of MMP-1 and MMP-9 in both groups were significantly lower than those before operation, and the above indexes in the observation group were significantly lower than those in the control group. The levels of LVEF and TIMP-1 in serum of the two groups were significantly higher than those before operation, which were higher in the observation group than that of the control group(P<0.05). No severe complication occurred in both groups. Conclusion: Valve surgery concomitant radiofrequency ablation modified maze is safe and effective in the treatment of atrial fibrillation complicated by valvular heart disease, has high conversion rate of early sinus rhythm, and can improve the serum levels of TIMP-1, MMP-1 and MMP-9.
- Subjects
HEART valve diseases; ATRIAL fibrillation; ARTIFICIAL blood circulation; HEART valves; CATHETER ablation; RADIO frequency therapy
- Publication
Progress in Modern Biomedicine, 2019, Vol 19, Issue 24, p4678
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2019.24.017