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- Title
遗传性骨病致病基因及相关miRNA的相互作用分析.
- Authors
李青山; 陈莉; 索艳晖; 李渊深; 谢延平; 张桂生
- Abstract
Objective: To screen the disease genes and its related miRNA, and to study the interaction between the two and the role of genetic bone disease. Methods: This study applied the method of bioinformatics, firstly analyzed pathogenic gene of genetic bone disease by mirwalk and "international standard classification of genetic bone disease". According to the screening out of the pathogenic genes, Used mirwalk's 10 prediction miRNA search engine function, searched for the disease genes related to miRNA, and the excel work table was used to analyze the target genes of miRNA, cytoscape software was used to analyze the interaction between pathogenic genes and miRNA. Results: This study was closely associated with genetic bone disease genes can be divided into four categories: The first category was osteogenesis imperfecta type gene such as COL1A1, COL1A2, etc; The second category was the decreased bone density genes such as ACVR1, ALX1, etc; The third category was the increased bone density genes such as CASR, DMTF1, etc; The fourth category was functional backbone participates in bone density increase genes such as TGFBR1, MYCN, etc. With osteogenesis imperfecta which most closely mirna was hsa-miR-26b, hsa-miR-19, hsa-miR-200c, the hsa-miR-138 and hsa-miR-505 were the most closely related to the decreased bone density, the mirna with most closely related to the increased bone density was hsa-miR-196a, hsa-miR-200b, hsa-miR-19b. Conclusion: Mirna play an important role in the pathogenesis of genetic bone disease by regulating pathogenic genes,which show that the above mirna may become a new therapeutic target of prenatal screening and clinical drugs.
- Subjects
BONE density; OSTEOGENESIS imperfecta; BONE diseases; PATHOLOGY; GENETIC disorders
- Publication
Progress in Modern Biomedicine, 2019, Vol 19, Issue 19, p3789
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2019.19.044