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- Title
慢性心力衰竭患者N端脑钠肽前体、脑钠肽与患者心脏超声参数及炎症因子的关系
- Authors
蔡珠虹; 赵静; 刘天佳; 王凌霄; 蒋栋
- Abstract
Objective: To investigate the relationship between N-terminal pro brain natriuretic peptide(NT-proBNP) and brain natriuretic peptide(BNP) and cardiac ultrasound parameters and inflammatory factors in patients with chronic heart failure(CHF).Methods: 135 cases of CHF who were treated in our hospital from March 2015 to February 2018 were selected as the study group.According to the cardiac function classification of New York cardiology Association(NYHA), the study group was divided into Ⅰ group with 26 cases, Ⅱclass with 34 cases, Ⅲ class with 42 cases, IV class with 33 cases.Another 30 healthy volunteers who received physical examination in the same period were selected as control group. The serum markers,inflammatory factors and cardiac function parameters of the control group and the study group, the NYHA group were compared.Pearson correlation analysis was used to analyze the correlation between NT-proBNP and BNP and inflammatory factors and echocardiography parameters. Results: The serum BNP,NT-pro BNP, interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), hypersensitive C reactive protein(hs-CRP), left ventricular end diastolic diameter(LVEDD) and left ventricular end systolic diameter(LVESD) were significantly higher than those in the control group,the left ventricular ejection fraction(LVEF) was lower than that of the control group(P<0.05). The level of BNP, NT-proBNP, IL-6,TNF-α, hs-CRP and LVEDD and LVESD increased with the increase of cardiac function classification, and LVEF decreased with the increase of following function classification(P<0.05). Pearson correlation analysis showed that BNP and NT-proBNP in CHF patients were positivelycorrelated with IL-6,TNF-α, hs-CRP, LVEDD and LVESD, but negatively correlated with LVEF(P<0.05). Conclusion:Serum NT-proBNP and BNP are closely related to CHF echocardiographic parameters and inflammatory factors. It may be considered as a biological marker for clinical diagnosis of CHF.
- Publication
Progress in Modern Biomedicine, 2019, Vol 19, Issue 8, p1459
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2019.08.013