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- Title
氧化苦参碱对哮喘大鼠肺组织IL-10 表达的影响.
- Authors
龙兴云; 张平; 刘艳丰; 邓湘; 欧立文
- Abstract
Objective: To observe the influence of the different concentration of Oxymatrine on the level of IL-10 in lung tissues of asthmatic rats and explore its mechanism. Methods: 40 healthy female SD rats were randomly divided into five groups: A: the asthma model group(OVA), B: low concentration group(Oxy 50 mg/kg), C: mediumconcentration group(Oxy 100 mg/kg), D: high concentration group (Oxy 150 mg/kg) and E: Control group (normal saline). The rats were killed when they were nebulizated after 24 hours. The histological change of lung tissues was observed by HE staining. The expression of IL-10 in lung tissues was measured by RT-PCR and Western blot. Results: HE stainging demonstrated that a large number of inflammatory cells infiltration existed in lung tissues of asthmatic group, airway smooth muscle became think, excessive collagen deposition, but it did not obviously change in control group. inflammatory cells infiltration in lung tissues and airway smooth muscle change in different concentrations of oxymatrine drugs groups were gradually reduced. The expressions of IL-10 in asthma model group, low concentration group and medium concentration group was lower than that of control group (P<0.05), but The expressions of IL-10 in high concentration group had no significant differences compared with control group (P>0.05); The expressions of IL-10 in medium concentration group and high concentration group was higher than asthma model group (P<0.05), but the expressions of IL-10 in low concentration group had no significant differences compared with asthma model group (P>0.05).Conclusion: Oxymatrine can promote the expression of IL-10 in asthmatic rats, which was positively correlated in the concentration range of Oxy.
- Publication
Progress in Modern Biomedicine, 2016, Vol 16, Issue 16, p3036
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2016.16.009