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- Title
Myo-Inositol Biosynthesis Genes in Arabidopsis: Differential Patterns of Gene Expression and Role in Cell Death.
- Authors
Eckardt, Nancy A.
- Abstract
This article discusses the role of myo-inositol biosynthesis genes in Arabidopsis, specifically focusing on the three genes encoding l-myo-inositol 1-phosphate synthase (MIPS) proteins. The study found that MIPS1 is the most highly expressed gene in all tissues and plays a crucial role in myo-inositol biosynthesis in mature plants. Loss-of-function mips1 mutant plants had lower levels of myo-inositol, higher levels of ceramides, and increased sensitivity to stress-induced cell death. The researchers hypothesize that the accumulation of ceramides due to the reduction in myo-inositol leads to cell death. This study provides valuable insights into the functional divergence of MIPS genes and the regulation of ceramide metabolism and cell death.
- Subjects
CELL death; GENE expression; BIOSYNTHESIS; ARABIDOPSIS; GENES
- Publication
Plant Cell, 2010, Vol 22, Issue 3, p537
- ISSN
1040-4651
- Publication type
Article
- DOI
10.1105/tpc.110.220310