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- Title
Cardiovascular disease outcomes in metabolically healthy obesity in communities of Beijing cohort study.
- Authors
Li, Lin; Chen, Kang; Wang, An‐Ping; Gao, Jie‐Qing; Zhao, Kun; Wang, Hai‐Bin; Dou, Jing‐Tao; Lv, Zhao‐Hui; Wang, Bao‐An; Yan, Wen‐Hua; Yang, Lin‐Lin; Mu, Yi‐Ming; Wang, An-Ping; Gao, Jie-Qing; Wang, Hai-Bin; Dou, Jing-Tao; Lv, Zhao-Hui; Wang, Bao-An; Yan, Wen-Hua; Yang, Lin-Lin
- Abstract
<bold>Objective: </bold>The objective of this study was to investigate the association between metabolically healthy obese (MHO) phenotype and the risk of cardiovascular disease (CVD).<bold>Methods: </bold>A total of 9393 subjects aged ≥40 years were enrolled in the cohort study (2011-2015). The participants were stratified by body mass index category and metabolic risk at baseline, and incidence of CVD was ascertained at follow-up.<bold>Results: </bold>The MHO accounted for 6.7%. Compared with the metabolically healthy normal weight (MHNW) group, MHO subjects demonstrated increased risk of CVD events (HR = 1.91; 95% CI, 1.13-3.24). In people with obesity, there was no significant difference on increasing risk of incidence of CVD in the metabolically unhealthy individuals compared with metabolically healthy individuals (HR = 1.19; 95% CI, 0.74-1.91). Female (OR = 1.97; 95% CI, 1.06-3.64), smoking (OR = 2.09; 95% CI, 1.06-4.10), a larger waist circumference (OR = 1.07; 95% CI, 1.03-1.10) and higher LDL cholesterol levels (OR = 1.55; 95% CI, 1.20-2.00) were independent risk factors of the development of the MHO to the metabolically unhealthy obese (MUO) phenotype.<bold>Conclusions: </bold>The risk of CVD events of MHO phenotypes is similar to MUO phenotypes; both are higher than the MHNW phenotypes.
- Publication
International Journal of Clinical Practice, 2019, Vol 73, Issue 3, pN.PAG
- ISSN
1368-5031
- Publication type
journal article
- DOI
10.1111/ijcp.13279