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- Title
Rapid Diagnosis of Hemophagocytic Lymphohistiocytosis Triggered by Disseminated BCG Infection in Infants With Severe Combined Immunodeficiency: Case Report.
- Authors
Zou, Ting-Ting; Liao, Qiong; Liu, Yang; Guo, Qin; Zhu, Yu; Wan, Chao-min
- Abstract
Hemophagocytic lymphohistiocytosis triggered by disseminated Bacillus Calmette-Guerin infection is rare. Targeted next-generation sequencing for tuberculosis can rapidly identify different strains of Mycobacterium tuberculosis complex as well as drug resistance genes. Herein we report 2 cases of hemophagocytic lymphohistiocytosis in whom targeted next-generation sequencing rapidly identified Bacillus Calmette-Guerin as the infectious trigger.
- Subjects
HEMOPHAGOCYTIC lymphohistiocytosis; SEVERE combined immunodeficiency; NUCLEOTIDE sequencing; MYCOBACTERIUM tuberculosis; DIAGNOSIS; INFANTS
- Publication
Open Forum Infectious Diseases, 2023, Vol 10, Issue 11, p1
- ISSN
2328-8957
- Publication type
Case Study
- DOI
10.1093/ofid/ofad548