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- Title
Ultra low dose CT screen-detected non-malignant incidental findings in the Western Australian Asbestos Review Programme.
- Authors
Murray, Conor P.; Wong, Patrick M.; Teh, Joelin; de Klerk, Nick; Rosenow, Tim; Alfonso, Helman; Reid, Alison; Franklin, Peter; Musk, A. W. (Bill); Brims, Fraser J. H.
- Abstract
Background and objective Computed tomography (CT)-based studies of asbestos-exposed individuals report a high prevalence of lung cancer, but the utility of low dose CT (LDCT) to screen asbestos-exposed populations is not established. We aimed to describe the prevalence of indeterminate pulmonary nodules and incidental findings on chest LDCT of asbestos-exposed subjects in Western Australia. Methods A total of 906 subjects from the Western Australian Asbestos Review Programme underwent LDCT of the chest as part of regular annual review. An indeterminate (solid) nodule was defined as >50 mm3 and part-solid/non-solid nodules >5 mm. The presence of asbestos-related diseases was recorded with a standardized report. Results Subjects were mostly (81%) men with a median age of 70 years. Fifty-eight (6.5%) participants were current smokers, 511 (56.4%) ex-smokers and 325 (36.4%) never-smokers. One hundred and four indeterminate nodules were detected in 77 subjects (8.5%); of these, eight cases had confirmed lung cancer (0.88%). Eighty-seven subjects (9.6%) had incidental findings that required further investigation, 42 (4.6%) from lower airways inflammation. The majority of nodules were solid, 4-6 mm and more common with age. Five hundred and eighty (64%) subjects had pleural plaques, and 364 (40.2%) had evidence of interstitial lung disease. Conclusion The prevalence of LDCT-detected indeterminate lung nodules in 906 individuals with significant asbestos exposure was 8.5%, lower than many other CT studies. Clinically important incidental findings were found in 9.4%, predominantly related to lower respiratory tract inflammation. LDCT appears to effectively describe asbestos-related diseases and is likely to be an acceptable modality to monitor asbestos-exposed individuals.
- Subjects
COMPUTED tomography; ASBESTOS &; health; LUNG cancer; DISEASE prevalence; DISEASE reservoirs (Public health)
- Publication
Respirology, 2016, Vol 21, Issue 8, p1419
- ISSN
1323-7799
- Publication type
Article
- DOI
10.1111/resp.12826