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- Title
Maleopimaric acid--a potent sensitizer in modified rosin.
- Authors
Ann-Therese Karlberg, Jaine; Elisabeth Fafvert, Jaine; Gunnel Hagelthorn, Jaine; J. Lars G. Nilsson
- Abstract
The allergenicity of the maleic-modified rosins and their esters has been studied. The unesterified resins are mainly used in paper size and the esters in printing inks, varnishes and adhesives. The levopimaric-maleic anhydride Diels-Alder adduct (maleopimaric acid) is the main component obtained in the maleic-modified resins. This compound was synthesized and its structure was determined. Its sensitizing potential was investigated in guinea pigs according to different methods. It was shown that maleopimaric acid is a very potent sensitizer, comparable with the strongest allergen isolated from unmodified gum rosin. The allergen may also be present after esterification unless the process is carried out to completion. The animals sensitized to maleopimaric acid did not react to unmodified rosin, which shows that maleopimaric acid is structurally different from the allergens in rosin.
- Subjects
ALLERGENS; GUMS &; resins; PRINTING ink; ADHESIVES; GUINEA pigs as laboratory animals; DIELS-Alder reaction; ESTERIFICATION
- Publication
Contact Dermatitis (01051873), 1990, Vol 22, Issue 4, p193
- ISSN
0105-1873
- Publication type
Article
- DOI
10.1111/j.1600-0536.1990.tb01566.x