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- Title
Vitamin E and enzymatic/oxidative stress-driven oxysterols in amnestic mild cognitive impairment subtypes and Alzheimer's disease.
- Authors
Iuliano L; Monticolo R; Straface G; Spoletini I; Gianni W; Caltagirone C; Bossù P; Spalletta G; Iuliano, Luigi; Monticolo, Roberto; Straface, Giuseppe; Spoletini, Ilaria; Gianni, Walter; Caltagirone, Carlo; Bossù, Paola; Spalletta, Gianfranco
- Abstract
Oxidative stress,which contributes to neuronal damage, is thought to be a pathophysiologicalmechanism of Alzheimer's disease (AD). Markers of oxidative stress may appear early in the preclinical, mild cognitive impairment (MCI) phase of AD.We investigated the interaction among enzymatic-derived oxysterols (24S-hydroxycholesterol and 27-hydroxycholesterol), markers of oxidative stress, including free radical-related oxysterols (7 hydroxycholesterol and 7-ketocholesterol), and vitamin E in AD patients and two amnestic MCI subtypes, amnestic single-domain MCI (a-MCI) subjects, and multidomain MCI (md-MCI) subjects, compared to healthy control subjects (HC). The study included 37 patients with AD, 24 with a-MCI, 29 with md-MCI, and 24 HC. Plasma assessments were made using isotope dilution-mass spectrometry. Although we found no significant change in free radical- or enzymatic-derived oxysterol concentrations in AD or MCI patients, vitamin E levels corrected for cholesterol were reduced in AD patients compared to HC. Results suggest that AD patients have upregulated cerebral oxidative stress or a nutritional deficit of vitamin E. The oxysterols investigated here are not useful markers for diagnosing AD or MCI.
- Subjects
ALZHEIMER'S disease diagnosis; ALZHEIMER'S disease; BIOMARKERS; AMNESIA; CHOLESTEROL; COGNITION disorders; VITAMIN E; OXIDATIVE stress; PSYCHOLOGICAL factors; PSYCHOLOGY; DIAGNOSIS
- Publication
Journal of Alzheimer's Disease, 2010, Vol 21, Issue 4, p1383
- ISSN
1387-2877
- Publication type
journal article