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- Title
CD11b deficiency suppresses intestinal tumor growth by reducing myeloid cell recruitment.
- Authors
Zhang, Qian-Qian; Hu, Xi-Wen; Liu, Yi-Long; Ye, Zhi-Jin; Gui, Yi-He; Zhou, Da-Lei; Qi, Cui-Ling; He, Xiao-Dong; Wang, Honglin; Wang, Li-Jing
- Abstract
Mac-1 (CD11b) is expressed on bone marrow-derived immune cells. CD11b binds to ligands to regulate leukocyte adhesion and migration across the endothelium or epithelium. Here, we employed CD11b knockout mice and an ApcMin/+ spontaneous intestinal adenoma mouse model to clarify the function of CD11b in intestinal tumorigenesis. We showed that CD11b deficiency may contribute to the inhibition of myeloid cell trafficking to the tumor microenvironment and inactivated Wnt/β-catenin pathway to suppress tumor growth. This effect was partly mediated by inhibiting the myeloid cell-mediated decrease in TNF-α secretion, which inhibits the recruitment of myeloid-derived suppressor cells to the tumor microenvironment and subsequently induces IFN-γ and CXCL9 production. This work provides evidence for the mechanism by which CD11b may function as an important oncogene and highlights the potential of CD11b as a therapeutic target in CRC.
- Subjects
TUMOR growth; MYELOID leukemia; LEUCOCYTES; ENDOTHELIUM; ENDOTHELIAL cells
- Publication
Scientific Reports, 2015, p15948
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep15948