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- Title
Anti-cancer small molecule JP-8g exhibits potent in vivo anti-inflammatory activity.
- Authors
Yulong Sun; Jia Liu; Tao Sun; Xiaoyuan Zhang; Jia Yao; Ming Kai; Xianxing Jiang; Rui Wang
- Abstract
Spirooxindoles are a class of compounds with diverse biological activity. Previously, we identified a series of spirooxindole-pyranopyrimidine compounds that exhibited broad-spectrum anti-cancer activity. In this study, we evaluated one of these compounds, JP-8g, on mouse models and found that it showed potent in vivo anti-inflammatory activity. Further investigation suggested that JP-8g may execute its anti-inflammatory activity through nitric oxide synthase signaling pathways. Our results suggest that these spirooxindole-pyranopyrimidine class compounds have potential for not only cancer treatment but also inflammation therapy.
- Subjects
ANTINEOPLASTIC agents; NITRIC-oxide synthases; INFLAMMATION treatment; ANTI-inflammatory agents; LABORATORY mice
- Publication
Scientific Reports, 2014, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep04372