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- Title
Biosynthesis of Medium- to Long-Chain α,ω-Diols from Free Fatty Acids Using CYP153A Monooxygenase, Carboxylic Acid Reductase, and E. coli Endogenous Aldehyde Reductases.
- Authors
Ahsan, Md Murshidul; Sung, Sihyong; Jeon, Hyunwoo; Patil, Mahesh D.; Chung, Taeowan; Yun, Hyungdon
- Abstract
α,ω-Diols are important monomers widely used for the production of polyesters and polyurethanes. Here, biosynthesis of α,ω-diols (C8-C16) from renewable free fatty acids using CYP153A monooxygenase, carboxylic acid reductase, and E. coli endogenous aldehyde reductases is reported. The highest yield of α,ω-diol was achieved for the production of 1,12-dodecanediol. In the nicotinamide adenine dinucleotide phosphate (NADPH) cofactor regeneration system, 5 g/L of 1,12-dodecanediol was synthesized in 24 h reaction from the commercial ω-hydroxy dodecanoic acid. Finally, 1.4 g/L 1,12-dodecanediol was produced in a consecutive approach from dodecanoic acids. The results of this study demonstrated the scope of the potential development of bioprocesses to substitute the petroleum-based products in the polymer industry.
- Subjects
GLYCOL synthesis; CHEMICAL alcohol synthesis; ESCHERICHIA coli biotechnology
- Publication
Catalysts (2073-4344), 2018, Vol 8, Issue 1, p4
- ISSN
2073-4344
- Publication type
Article
- DOI
10.3390/catal8010004