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- Title
Meta-analysis: the efficacy of anti-viral therapy in prevention of recurrence after curative treatment of chronic hepatitis B-related hepatocellular carcinoma.
- Authors
Wong, J. S.‐W.; Wong, G. L.‐H.; Tsoi, K. K.‐F.; Wong, V. W.‐S.; Cheung, S. Y.‐S.; Chong, C.‐N.; Wong, J.; Lee, K.‐F.; Lai, P. B.‐S.; Chan, H. L.‐Y.
- Abstract
Background The role of anti-viral therapy in prevention of hepatocellular carcinoma (HCC) recurrence is to be defined. Aim To investigate the role of anti-viral therapy in prevention of tumour recurrence after curative treatment of hepatitis B virus (HBV)-related HCC. Methods A systematic electronic search on keywords including HCC and different anti-viral therapies was performed through eight electronic databases, including Medline, EMBASE and Cochrane Databases. The primary outcome was HCC recurrence after curative treatment of HBV-related HCC. The secondary outcomes were mortality related to HCC, mortality related to liver failure and the overall mortality. Results Nine cohort studies were included with a total number of 551 patients: 204 patients with anti-viral treatment group and 347 patients without anti-viral treatment (control group). There was significant difference in the incidence of HCC recurrence in favour of the anti-viral treatment group (55% vs. 58%; odds risk (OR) = 0.59, 95% CI 0.35-0.97, P = 0.04). The risk of HCC was reduced by 41% in the anti-viral treatment group. There were also significant differences in favour of anti-viral treatment group in terms of liver-related mortality (0% vs. 8%; OR = 0.13, 95% CI 0.02-0.69, P = 0.02) and overall mortality (38% vs. 42%; OR = 0.27, 95% CI 0.14-0.50, P < 0.001). Conclusions Anti-viral therapy has potential beneficial effects after the curative treatment of HBV-related hepatocellular carcinoma in terms of tumour recurrence, liver-related mortality and overall survival. Anti-viral therapy should be considered after curative treatment of hepatocellular carcinoma.
- Subjects
META-analysis; VIRAL hepatitis; CHRONIC diseases; HEPATITIS B; CANCER; LIVER diseases
- Publication
Alimentary Pharmacology & Therapeutics, 2011, Vol 33, Issue 10, p1104
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2011.04634.x