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- Title
Serum Vascular Endothelial Growth Factor as a Possible Prognostic Indicator in Sarcoidosis.
- Authors
Sekiya, M.; Ohwada, A.; Miura, K.; Takahashi, S.; Fukuchi, Y.
- Abstract
Sarcoidosis is a systemic granulomatous disorder of unknown etiology, which involves the lung, eye, liver, and other organs. Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis involved in an important role in the development of granuloma. However, only a limited number of studies have reported on the relationship between serum VEGF values and the clinical status of sarcoidosis. We investigated the correlation between serum VEGF values and extent of disease, prognosis, and radiographic stage compared with serum angiotensin converting enzyme (ACE) values as another candidate. Concentrations of serum VEGF in patients who received corticosteriod treatment were significantly higher than those of patients with spontaneous remission (p < 0.05). In addition, serum VEGF administration of corticosteroid involvements. We concluded that serum VEGF values in patients with sarcoidosis is a predictive factor in determining extrathoracic organ involvements and as a parameter for deciding the necessity of treatment with corticosteroid. Serum VEGF might be a useful marker as a prognostic indicator in sarcoidosis.
- Subjects
SARCOIDOSIS; LYMPHOPROLIFERATIVE disorders; GROWTH factors; CHRONIC granulomatous disease; NEOVASCULARIZATION
- Publication
Lung, 2003, Vol 181, Issue 5, p259
- ISSN
0341-2040
- Publication type
Article
- DOI
10.1007/s00408-003-1028-8