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- Title
Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury.
- Authors
Martin, Jack L.; Gruszczyk, Anja V.; Beach, Timothy E.; Murphy, Michael P.; Saeb-Parsy, Kourosh
- Abstract
Acute kidney injury (AKI) remains a major problem in critically unwell children and young adults. Ischaemia reperfusion (IR) injury is a major contributor to the development of AKI in a significant proportion of these cases and mitochondria are increasingly recognised as being central to this process through generation of a burst of reactive oxygen species early in reperfusion. Mitochondria have additionally been shown to have key roles in downstream processes including activation of the immune response, immunomodulation, and apoptosis and necrosis. The recognition of the central role of mitochondria in IR injury and an increased understanding of the pathophysiology that undermines these processes has resulted in identification of novel therapeutic targets and potential biomarkers. This review summarises a variety of therapeutic approaches that are currently under exploration and may have potential in ameliorating AKI in children in the future.
- Subjects
ACUTE kidney failure; REACTIVE oxygen species; APOPTOSIS; BIOMARKERS; IMMUNE system; MITOCHONDRIA; MOLECULAR structure; NECROSIS; PEDIATRICS; REPERFUSION injury; DISEASE complications; CHILDREN; DISEASE risk factors
- Publication
Pediatric Nephrology, 2019, Vol 34, Issue 7, p1167
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-018-3984-5