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- Title
BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl.
- Authors
Hemmeryckx, Bianca; Reichert, Anja; Watanabe, Meguru; Kaartinen, Vesa; de Jong, Ron; Pattengale, Paul K.; Groffen, John; Heisterkamp, Nora
- Abstract
Presents a study on the development of leukemia in transgenic mice in the absence of adapter protein Crkl. Role of Crkl in transducing oncogenic signals of Bcr/Abl fusion protein; Correlation between the consistent and abnormal tyrosine phosphorylation of Crkl and Bcr/Abl; Involvement of Crk in leukemia caused by P190 in transgenic mice.
- Subjects
LEUKEMIA; TRANSGENIC mice; PROTEINS
- Publication
Oncogene, 2002, Vol 21, Issue 20, p3225
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1205452