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- Title
The expression of SOCS is altered in rheumatoid arthritis.
- Authors
Isomäki, P.; Alanärä, T.; Isohanni, P.; Lagerstedt, A.; Korpela, M.; Moilanen, T.; Visakorpi, T.; Silvennoinen, O.
- Abstract
Objectives. Cytokines play a key pathogenic role in rheumatoid arthritis (RA). Several cytokines signal through the JAK-STAT pathway, which is negatively regulated by the suppressors of cytokine signalling (SOCS) proteins. Since SOCS protein levels can profoundly modulate cellular responses to cytokines, we have investigated their expression in chronic RA.
- Subjects
CYTOKINES; SUPPRESSOR cells; PROTEINS; RHEUMATOID arthritis; CELLULAR signal transduction
- Publication
Rheumatology, 2007, Vol 46, Issue 10, p1538
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/kem198