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- Title
Helicobacter pylori infection in psoriasis: results of a clinical study and review of the literature.
- Authors
Campanati, Anna; Ganzetti, Giulia; Martina, Emanuela; Giannoni, Melania; Gesuita, Rosaria; Bendia, Emanuele; Giuliodori, Katia; Sandroni, Lucia; Offidani, Annamaria
- Abstract
Background Data from the literature concerning the role of Helicobacter pylori (H. pylori) infection in psoriasis are still conflicting. This study was carried out to evaluate prevalence of H. pylori in patients with mild to severe psoriasis, correlation between H. pylori infection and severity of psoriasis, and effect of H. pylori eradication on the clinical course of psoriasis. Methods Two hundred and ten patients with psoriasis and 150 healthy controls were screened for H. pylori through [13C] urea breath test at baseline (T0). All patients with psoriasis received standardized phototherapy treatment, and those infected by H. pylori were also treated with a 1-week triple therapy, then they were all re-evaluated four weeks later at the end of therapy (T5). Results The prevalence of H. pylori was not higher in psoriasis than in the control group (20.27 vs. 22%; P > 0.05). Patients infected by H. pylori showed more severe psoriasis than uninfected patients (psoriasis area and severity index score 17.9 ± 7.1 vs. 13.7 ± 6.9; P = 0.04), and patients who received successful eradication of H. pylori infection showed a greater improvement of psoriasis than the others (psoriasis area and severity index score at T5 in patients infected by H. pylori was 8.36 ± 3.76, in uninfected patients was 10.85 ± 3.49; P = 0.006). Conclusions Patients with mild to severe psoriasis do not show a greater prevalence of H. pylori infection; however, H. pylori seems able to affect the clinical severity of psoriasis.
- Subjects
HELICOBACTER pylori; HELICOBACTER pylori infections; PSORIASIS; PHOTOTHERAPY; SKIN diseases
- Publication
International Journal of Dermatology, 2015, Vol 54, Issue 5, pe109
- ISSN
0011-9059
- Publication type
Article
- DOI
10.1111/ijd.12798