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- Title
Patients With Lean Nonalcoholic Fatty Liver Disease Are Metabolically Abnormal and Have a Higher Risk for Mortality.
- Authors
Golabi, Pegah; Paik, James; de Avilla, Leyla; Younossi, Zobair M.; Natsu Fukui; Locklear, Cameron T.
- Abstract
Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized and common cause of chronic liver disease worldwide. Although most patients with NAFLD are obese, a smaller group of NAFLD patients arelean. This study explored the long-term outcomes of lean patients with NAFLD in the United States. Compared to lean individuals without NAFLD, lean people with NAFLD were significantly more likely to be older and male and had higher comorbidities (i.e., diabetes, hyperlipidemia, hypertension, metabolic syndrome, chronic kidney disease, and cardiovascular disease). The presence of NAFLD in lean individuals was independently associated with increased risk of all-cause and cardiovascular mortality.
- Subjects
UNITED States; CARDIOVASCULAR disease related mortality; METABOLIC disorders; MORTALITY risk factors; CARDIOVASCULAR diseases risk factors; CHRONIC kidney failure; DIABETES; FATTY liver; HYPERLIPIDEMIA; HYPERTENSION; LEANNESS; COMORBIDITY; METABOLIC syndrome; DISEASE risk factors
- Publication
Clinical Diabetes, 2019, Vol 37, Issue 1, p65
- ISSN
0891-8929
- Publication type
Article
- DOI
10.2337/cd18-0026