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- Title
Targeting the Peroxisome Proliferator-Activated Receptor-γ to Counter the Inflammatory Milieu in Obesity.
- Authors
Corzo, Cesar; Griffin, Patrick R.
- Abstract
Adipose tissue, which was once viewed as a simple organ for storage of triglycerides, is now considered an important endocrine organ. Abnormal adipose tissue mass is associated with defects in endocrine and metabolic functions which are the underlying causes of the metabolic syndrome. Many adipokines, hormones secreted by adipose tissue, regulate cells from the immune system. Interestingly, most of these adipokines are proinflammatory mediators, which increase dramatically hi the obese state and are believed to be involved in the pathogenesis of insulin resistance. Drugs that target peroxisome proliferator-activated receptor-γ have been shown to possess anti-inflammatory effects in animal models of diabetes. These findings, and the link between inflammation and the metabolic syndrome, will be reviewed here.
- Subjects
PEROXISOMES; MICROBODIES; OBESITY; BODY weight; DIABETES
- Publication
Diabetes & Metabolism Journal, 2013, Vol 37, Issue 6, p395
- ISSN
2233-6079
- Publication type
Article
- DOI
10.4093/dmj.2013.37.6.395